VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00106655" target="_blank" >RIV/00216224:14740/18:00106655 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/nar/gkx760" target="_blank" >http://dx.doi.org/10.1093/nar/gkx760</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/nar/gkx760" target="_blank" >10.1093/nar/gkx760</a>
Alternative languages
Result language
angličtina
Original language name
VDJdb: a curated database of T-cell receptor sequences with known antigen specificity
Original language description
The ability to decode antigen specificities encapsulated in the sequences of rearranged T-cell receptor (TCR) genes is critical for our understanding of the adaptive immune system and promises significant advances in the field of translational medicine. Recent developments in high-throughput sequencing methods (immune repertoire sequencing technology, or RepSeq) and single-cell RNA sequencing technology have allowed us to obtain huge numbers of TCR sequences from donor samples and link them to T-cell phenotypes. However, our ability to annotate these TCR sequences still lags behind, owing to the enormous diversity of the TCR repertoire and the scarcity of available data on T-cell specificities. In this paper, we present VDJdb, a database that stores and aggregates the results of published T-cell specificity assays and provides a universal platform that couples antigen specificities with TCR sequences. We demonstrate that VDJdb is a versatile instrument for the annotation of TCR repertoire data, enabling a concatenated view of antigen-specific TCR sequence motifs. VDJdb can be accessed at https://vdjdb.cdr3. net and https://github.com/antigenomics/vdjdb-db.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nucleic Acids Research
ISSN
0305-1048
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
D1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
„D419“-„D427“
UT code for WoS article
000419550700064
EID of the result in the Scopus database
2-s2.0-85040922139