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Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00108506" target="_blank" >RIV/00216224:14740/19:00108506 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/19:00071136

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15922" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/bjh.15922</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/bjh.15922" target="_blank" >10.1111/bjh.15922</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Detection of a deletion at 22q11 locus involving ZNF280A/ZNF280B/PRAME/GGTLC2 in B-cell malignancies: simply a consequence of an immunoglobulin lambda light chain rearrangement

  • Original language description

    In this journal, Mestichelli et al (2018) recently reported that a submicroscopic 22q11 deletion is a potentially significant genomic aberration in chronic lymphocytic leukaemia (CLL), and that this alteration is missed by current routine techniques. This was based on the analysis of 23 CLL cases by oligonucleotide-based array comparative genomic hybridisation (aCGH; CytoChipCancer 4x180K, Illumina). The authors found 4 CLL cases with a deletion located at 22q11 that ranged in size from 0.68 Mb–0.49 Mb. The authors claimed that the minimally deleted region included the ZNF280A, ZNF280B, GGTLC2 and PRAME genes. The deletion in the 22q11 region was originally described by Gunn et al (2009) using aCGH and detected in 28 out of 187 analysed CLL cases.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30205 - Hematology

Result continuities

  • Project

    <a href="/en/project/NV18-03-00054" target="_blank" >NV18-03-00054: THE ROLE OF MICRORNAS AND THEIR TARGETS IN THE TRANSFORMATION OF FOLLICULAR LYMPHOMA AND AGGRESSIVENESS OF CHRONIC LYMPHOCYTIC LEUKEMIA</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    British journal of haematology

  • ISSN

    0007-1048

  • e-ISSN

  • Volume of the periodical

    186

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    4

  • Pages from-to

    „E91“-„E94“

  • UT code for WoS article

    000478608100010

  • EID of the result in the Scopus database

    2-s2.0-85064496995