Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F19%3A00108591" target="_blank" >RIV/00216224:14740/19:00108591 - isvavai.cz</a>
Result on the web
<a href="https://bmcvetres.biomedcentral.com/track/pdf/10.1186/s12917-019-2154-8" target="_blank" >https://bmcvetres.biomedcentral.com/track/pdf/10.1186/s12917-019-2154-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12917-019-2154-8" target="_blank" >10.1186/s12917-019-2154-8</a>

Result language
angličtina
Original language name
Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog
Original language description
Background Evolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma. Differentiation of these scenarios can be aided by next generation sequencing (NGS)-based assessment of clonality of lymphocyte antigen receptor genes. Case presentation An 8-year-old male intact Mastiff presented with generalized lymphadenomegaly was diagnosed with nodal T zone lymphoma (TZL) based on cytology, histopathology, immunohistochemistry and flow cytometry. Thirteen months later, the dog re-presented with progressive lymphadenomegaly, and based on cytology and flow cytometry, a large B cell lymphoma (LBCL) was diagnosed. Sequencing-based clonality testing confirmed the de novo development of a LBCL and the persistence of a TZL. Conclusions The occurrence of two distinct lymphoid neoplasms should be considered if patient features and tumor cytomorphology or immunophenotype differ among sequential samples. Sequencing-based clonality testing may provide conclusive evidence of two concurrent and distinct clonal lymphocyte populations, termed most appropriately "composite lymphoma".
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
40301 - Veterinary science

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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