Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00117301" target="_blank" >RIV/00216224:14740/20:00117301 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1002/hbm.25163" target="_blank" >https://doi.org/10.1002/hbm.25163</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/hbm.25163" target="_blank" >10.1002/hbm.25163</a>

Result language

angličtina

Original language name

Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood

Original language description

Maternal stress during pregnancy and shortly thereafter is associated with altered offspring brain development that may increase risk of mood and anxiety disorders. Cortical gyrification is established during the prenatal period and the first 2 years of life and is altered in psychiatric disorders. Here, we sought to characterize the effects of perinatal stress exposure on offspring gyrification patterns and mood dysregulation in young adulthood. Participants included 85 young adults (56.5% women; 23-24 years) from the European Longitudinal Study of Pregnancy and Childhood (ELSPAC) with perinatal stress data across four distinct timepoints and structural MRI data from young adulthood. Perinatal stress exposure was measured as maternal stress during first and second half of pregnancy, first 6 months, and 6-18 months after birth. Cortical gyrification and mood dysregulation were quantified using local gyrification index (LGI), computed with Freesurfer, and the Profile of Mood States questionnaire, respectively. Perinatal stress predicted cortical gyrification in young adulthood, and its timing influenced location, direction, and sex-specificity of effects. In particular, whereas early prenatal stress was associated with sex-dependent medium-to-large effects in large temporal, parietal, and occipital regions (f(2)= 0.19-0.38,p&lt; .001), later perinatal stress was associated with sex-independent small-to-medium effects in smaller, more anterior regions (f(2)= 0.10-0.19,p&lt; .003). Moreover, in females, early prenatal stress predicted higher LGI in a large temporal region, which was further associated with mood disturbance in adulthood (r= 0.399,p= .006). These findings point out the long-term implications of perinatal stress exposure for cortical morphology and mood dysregulation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Human Brain mapping

ISSN

1065-9471

e-ISSN

1097-0193

Volume of the periodical

41

Issue of the periodical within the volume

17

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

4866-4875

UT code for WoS article

000574703300001

EID of the result in the Scopus database

2-s2.0-85092037579