The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F20%3A00118594" target="_blank" >RIV/00216224:14740/20:00118594 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/20:00072662
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1675877" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/10428194.2019.1675877</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/10428194.2019.1675877" target="_blank" >10.1080/10428194.2019.1675877</a>

Result language
angličtina
Original language name
The role of MYC in the transformation and aggressiveness of ?indolent? B-cell malignancies
Original language description
MYC was found to be involved in many germinal center derived lymphomas, and more recently in the histological transformation of indolent mature B-cell malignancies, such as follicular lymphoma (FL), chronic lymphocytic leukemia (CLL) and mucosa-associated lymphoid tissue lymphoma (MALT) to aggressive diffuse large B-cell lymphoma (DLBCL). Pathological MYC activity gain in lymphomas is able to overcome its regulation by repressors, which leads to bypassing the affinity-based selection of B-cells. Arguably the MYC activity gain is the most constantly observed phenomenon (>70% of cases) in transformed FL/MALT/CLL (Richter?s transformation) and co-occurs with specific aberrations such as the loss of p53, CDKN2A/B, or gain of BCL2/BCL6. Here we summarize recent progress in the understanding of MYC regulatory network in lymphoma B-cells and highlight its involvement in lymphomas? histological transformation by regulating cyclins, CDKs, p21, p27, BCL2, E2F, FOXP1, BCR signaling components, and non-coding microRNA (miRNA) genes such as miR-150, miR-29, miR-17-92, and miR-34a.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
<a href="/en/project/NV18-03-00054" target="_blank" >NV18-03-00054: THE ROLE OF MICRORNAS AND THEIR TARGETS IN THE TRANSFORMATION OF FOLLICULAR LYMPHOMA AND AGGRESSIVENESS OF CHRONIC LYMPHOCYTIC LEUKEMIA</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)