The genetic and epigenetic landscape of the Arabidopsis centromeres
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00119657" target="_blank" >RIV/00216224:14740/21:00119657 - isvavai.cz</a>
Result on the web
<a href="https://www.science.org/doi/10.1126/science.abi7489" target="_blank" >https://www.science.org/doi/10.1126/science.abi7489</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/science.abi7489" target="_blank" >10.1126/science.abi7489</a>
Alternative languages
Result language
angličtina
Original language name
The genetic and epigenetic landscape of the Arabidopsis centromeres
Original language description
Centromeres attach chromosomes to spindle microtubules during cell division and, despite this conserved role, show paradoxically rapid evolution and are typified by complex repeats. We used long-read sequencing to generate the Col-CEN Arabidopsis thaliana genome assembly that resolves all five centromeres. The centromeres consist of megabase-scale tandemly repeated satellite arrays, which support CENTROMERE SPECIFIC HISTONE H3 (CENH3) occupancy and are densely DNA methylated, with satellite variants private to each chromosome. CENH3 preferentially occupies satellites that show the least amount of divergence and occur in higher-order repeats. The centromeres are invaded by ATHILA retrotransposons, which disrupt genetic and epigenetic organization. Centromeric crossover recombination is suppressed, yet low levels of meiotic DNA double-strand breaks occur that are regulated by DNA methylation. We propose that Arabidopsis centromeres are evolving through cycles of satellite homogenization and retrotransposon-driven diversification.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10611 - Plant sciences, botany
Result continuities
Project
<a href="/en/project/GA21-03909S" target="_blank" >GA21-03909S: Unlocking evolutionary secrets of false flax and its relatives</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science
ISSN
0036-8075
e-ISSN
—
Volume of the periodical
374
Issue of the periodical within the volume
6569
Country of publishing house
US - UNITED STATES
Number of pages
88
Pages from-to
„840“-„+“
UT code for WoS article
000717915400028
EID of the result in the Scopus database
2-s2.0-85118956061