NMR Studies of Tau Protein in Tauopathies

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00123604" target="_blank" >RIV/00216224:14740/21:00123604 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fmolb.2021.761227/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fmolb.2021.761227/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmolb.2021.761227" target="_blank" >10.3389/fmolb.2021.761227</a>

Result language

angličtina

Original language name

NMR Studies of Tau Protein in Tauopathies

Original language description

Tauopathies, including Alzheimer's disease (AD), are the most troublesome of all age-related chronic conditions, as there are no well-established disease-modifying therapies for their prevention and treatment. Spatio-temporal distribution of tau protein pathology correlates with cognitive decline and severity of the disease, therefore, tau protein has become an appealing target for therapy. Current knowledge of the pathological effects and significance of specific species in the tau aggregation pathway is incomplete although more and more structural and mechanistic insights are being gained using biophysical techniques. Here, we review the application of NMR to structural studies of various tau forms that appear in its aggregation process, focusing on results obtained from solid-state NMR. Furthermore, we discuss implications from these studies and their prospective contribution to the development of new tauopathy therapies.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/LTAUSA18168" target="_blank" >LTAUSA18168: Selective NMR labelling as a tool for characterization of protein complexes involved in neurodegenerative diseases.</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Molecular Biosciences

ISSN

2296-889X

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

NOV

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

761227

UT code for WoS article

000727903000001

EID of the result in the Scopus database

2-s2.0-85120688263