Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F21%3A00124240" target="_blank" >RIV/00216224:14740/21:00124240 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.0c19273" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.0c19273</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.0c19273" target="_blank" >10.1021/acsami.0c19273</a>
Alternative languages
Result language
angličtina
Original language name
Target-Specific Magnetic Resonance Imaging of Human Prostate Adenocarcinoma Using NaDyF4-NaGdF4 Core Shell Nanoparticles
Original language description
We illustrate the development of NaDyF4-NaGdF4 core-shell nanoparticles (NPs) for targeting prostate cancer cells using a preclinical 9.4 T magnetic resonance imaging (MRI) of live animals. The NPs composed of paramagnetic Dy3+ and Gd3+ (T-2- and T-1-contrast agents, respectively) demonstrate proton relaxivities of r(1) = 20.2 mM(-1) s(-1) and r(2) = 32.3 mM(-1) s(-1) at clinical 3 T and r(1) = 9.4 mM(-1) s(-1) and r(2) = 144.7 mM(-1) s(-1) at preclinical 9.4 T. The corresponding relaxivity values per NP are r(1) = 19.4 x 105 mM(NP)(-1) s(-1) and r(2) = 33.0 x 10(5) mMNP(-1) s(-1) at 3 T and r(1) = 9.0 x 105 mM(NP)(-1) s(-1) and r(2) = 147.0 x 10(5) mM(NP)(-1) s(-1) at 9.4 T. In vivo active targeting of human prostate tumors grown in nude mice revealed docking of anti-prostate-specific membrane antigen (PSMA) antibody-tagged NPs at tumor sites post-24 h of their intravenous injection. On the other hand, in vivo passive targeting showed preferential accumulation of NPs at tumor sites only within 2 h of their injection, ascribed to the enhanced permeation and retention effect of the tumor. A biodistribution study employing the harvested organs of mice, post-24 h injection of NPs, quantified active targeting as nearly twice as efficient as passive targeting. These outcomes provide potential opportunities for noninvasive diagnosis using NaDyF4-NaGdF4 core-shell NPs for target-specific MRI.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20601 - Medical engineering
Result continuities
Project
<a href="/en/project/LM2018129" target="_blank" >LM2018129: National Infrastructure for Biological and Medical Imaging Czech-BioImaging</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS APPLIED MATERIALS & INTERFACES
ISSN
1944-8244
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
21
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
24345-24355
UT code for WoS article
000659315800001
EID of the result in the Scopus database
2-s2.0-85107711501