Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F22%3A00129715" target="_blank" >RIV/00216224:14740/22:00129715 - isvavai.cz</a>
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1388245722008975?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388245722008975?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.clinph.2022.09.010" target="_blank" >10.1016/j.clinph.2022.09.010</a>
Alternative languages
Result language
angličtina
Original language name
Is non-invasive brain stimulation effective for cognitive enhancement in Alzheimer?s disease? An updated meta-analysis
Original language description
Objective: Alzheimer's disease dementia (AD) and its preclinical stage, mild cognitive impairment (MCI), are critical issues confronting the aging society. Non-invasive brain stimulation (NIBS) techniques have the potential to be effective tools for enhancing cognitive functioning. The main objective of our meta -analysis was to quantify and update the status of the efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) and Transcranial Direct Current Stimulation (tDCS) when applied in AD and MCI.Methods: The systematic literature search was conducted in PubMed and Web of Science according to PRISMA statement.Results: Pooled effect sizes (Hedges' g) from 32 studies were analyzed using random effect models. We found both, rTMS and tDCS to have significant immediate cognition-enhancing effect in AD with rTMS inducing also beneficial long-term effects. We found no evidence for synergistic effect of cognitive train-ing with NIBS.Conclusions: In AD a clinical recommendation can be made for NEURO-ADTM system and for high -frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC) as probably effective protocols (B -level of evidence) and for anodal tDCS over the left DLPFC as a possibly effective.Significance: According to scientific literature, NIBS may be an effective method for improving cognition in AD and possibly in MCI.(c) 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
<a href="/en/project/NV18-04-00256" target="_blank" >NV18-04-00256: The effect of transcranial direct current stimulation on visual attention in mild cognitive impairment – a combined MRI and non-invasive brain stimulation study</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Neurophysiology
ISSN
1388-2457
e-ISSN
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Volume of the periodical
144
Issue of the periodical within the volume
DEC
Country of publishing house
IE - IRELAND
Number of pages
18
Pages from-to
23-40
UT code for WoS article
000886064800004
EID of the result in the Scopus database
2-s2.0-85139366989