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RimM and RsfS ribosomal factors regulate the translation in bacteria

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00132139" target="_blank" >RIV/00216224:14740/23:00132139 - isvavai.cz</a>

  • Result on the web

    <a href="https://cssb.structbio.org/xix-discussions-in-structural-molecular-biology-and-6th-user-meeting-of-ciisb-czech-infrastructure-for-integrative-structural-biology/" target="_blank" >https://cssb.structbio.org/xix-discussions-in-structural-molecular-biology-and-6th-user-meeting-of-ciisb-czech-infrastructure-for-integrative-structural-biology/</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    RimM and RsfS ribosomal factors regulate the translation in bacteria

  • Original language description

    It is crucial for bacteria to save energy when stressed or the access to nutrients is limited. Since synthesis of proteins is an important energy draining source, bacteria rely on slowing down the protein synthesis in harsh conditions. The ribosomal silencing factor (RsfS) has a significant role in stalling the protein synthesis by binding the 50S ribosomal subunit and inhibiting the assembly of 70S ribosome. Meanwhile, the ribosomal maturation factor RimM is vital for the maturation of the 30S small ribosomal subunit. Moreover, during stress RimM is highly enriched in the hibernating 100S dimerized ribosome to stall the protein synthesis and preserve energy. In this work, we use a combination of biochemical studies and cryo-electron microscopy to elucidate the close relationship between RimM and RsfS, and their regulation capabilities on translation.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/LL2008" target="_blank" >LL2008: Crosstalk between transcription and translation</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů