Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00135359" target="_blank" >RIV/00216224:14740/24:00135359 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acs.jpclett.3c02785" target="_blank" >https://pubs.acs.org/doi/10.1021/acs.jpclett.3c02785</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acs.jpclett.3c02785" target="_blank" >10.1021/acs.jpclett.3c02785</a>
Alternative languages
Result language
angličtina
Original language name
Amphipathic Helices Can Sense Both Positive and Negative Curvatures of Lipid Membranes
Original language description
Curvature sensing is an essential ability of biomolecules to preferentially localize to membrane regions of a specific curvature. It has been shown that amphipathic helices(AHs),helical peptides with both hydrophilic and hydrophobic regions,could sense a positive membrane curvature.The origin of this AH sensing has been attributed to their ability to exploit lipid-packing defects that are enhanced in regions of positive curvature. In this study,we revisit an alternative framework where AHs act as sensors of local internal stress within the membrane,suggesting the possibility of an AH sensing a negative membrane curvature. Using molecular dynamics simulations, we gradually tuned the hydrophobicity of AHs, thereby adjusting their insertion depth so that the curvature preference of AHs is switched from positive to negative. This study suggests that highly hydrophobic AHs could preferentially localize proteins to regions of a negative membrane curvature.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of physical chemistry letters
ISSN
1948-7185
e-ISSN
1948-7185
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
175-179
UT code for WoS article
001141731800001
EID of the result in the Scopus database
2-s2.0-85181802800