An Insider's Perspective about the Pathogenic Relevance of Gut Bacterial Transportomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00139029" target="_blank" >RIV/00216224:14740/24:00139029 - isvavai.cz</a>

Result on the web

<a href="https://karger.com/mip/article/34/1/133/906299/An-Insider-s-Perspective-about-the-Pathogenic" target="_blank" >https://karger.com/mip/article/34/1/133/906299/An-Insider-s-Perspective-about-the-Pathogenic</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000538779" target="_blank" >10.1159/000538779</a>

Result language

angličtina

Original language name

An Insider's Perspective about the Pathogenic Relevance of Gut Bacterial Transportomes

Original language description

Background: The gut microbiome is integral to host health, hosting complex interactions between the host and numerous microbial species in the gastrointestinal tract. Key among the molecular mechanisms employed by gut bacteria are transportomes, consisting of diverse transport proteins crucial for bacterial adaptation to the dynamic, nutrient-rich environment of the mammalian gut. These transportomes facilitate the movement of a wide array of molecules, impacting both the host and the microbial community. Summary: This communication explores the significance of transportomes in gut bacteria, focusing on their role in nutrient acquisition, competitive interactions among microbes, and potential pathogenicity. It delves into the transportomes of key gut bacterial species like E. coli, Salmonella, Bacteroides, Lactobacillus, Clostridia, and Bifidobacterium, examining the functions of predicted transport proteins. The overview synthesizes recent research efforts, highlighting how these transportomes influence host-microbe interactions and contribute to the microbial ecology of the gut. Key Messages: Transportomes are vital for the survival and adaptation of bacteria in the gut, enabling the import and export of various nutrients and molecules. The complex interplay of transport proteins not only supports bacterial growth and competition but also has implications for host health, potentially contributing to pathogenic processes. Understanding the pathogenic potential of transportomes in major gut bacterial species provides insights into gut health and disease, offering avenues for future research and therapeutic strategies. (c) 2024 The Author(s). Published by S. Karger AG, Basel

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10606 - Microbiology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

MICROBIAL PHYSIOLOGY

ISSN

2673-1665

e-ISSN

—

Volume of the periodical

34

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

9

Pages from-to

133-141

UT code for WoS article

001316222900001

EID of the result in the Scopus database

2-s2.0-85195228650