Enhanced diffusion through multivalency

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F25%3A00140451" target="_blank" >RIV/00216224:14740/25:00140451 - isvavai.cz</a>
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2025/sm/d4sm00778f" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/sm/d4sm00778f</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/d4sm00778f" target="_blank" >10.1039/d4sm00778f</a>

Result language
angličtina
Original language name
Enhanced diffusion through multivalency
Original language description
The diffusion of macromolecules, nanoparticles, viruses, and bacteria is essential for targeting hosts or cellular destinations. While these entities can bind to receptors and ligands on host surfaces, the impact of multiple binding sites-referred to as multivalency-on diffusion along strands or surfaces is poorly understood. Through numerical simulations, we have discovered a significant acceleration in diffusion for particles with increasing valency, while maintaining the same overall affinity to the host surface. This acceleration arises from the redistribution of the binding affinity of the particle across multiple binding ligands. As a result, particles that are immobilized when monovalent can achieve near-unrestricted diffusion upon becoming multivalent. Additionally, we demonstrate that the diffusion of multivalent particles with a rigid ligand distribution can be modulated by patterned host receptors. These findings provide insights into the complex diffusion mechanisms of multivalent particles and biological entities, and offer new strategies for designing advanced nanoparticle systems with tailored diffusion properties, thereby enhancing their effectiveness in applications such as drug delivery and diagnostics.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10403 - Physical chemistry

Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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