Prediction of the Interaction between NK Cell Receptor KIR2DS4 and HLA-C*05-Peptide Complex
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F25%3A00143637" target="_blank" >RIV/00216224:14740/25:00143637 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/content/pdf/10.1134/S199074782570031X.pdf?utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://link.springer.com/content/pdf/10.1134/S199074782570031X.pdf?utm_source=clarivate&getft_integrator=clarivate</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1134/S199074782570031X" target="_blank" >10.1134/S199074782570031X</a>
Alternative languages
Result language
angličtina
Original language name
Prediction of the Interaction between NK Cell Receptor KIR2DS4 and HLA-C*05-Peptide Complex
Original language description
-The ability of NK cells to establish antigen-specific responses has been demonstrated in various infections. NK cell receptors of the diverse family of Killer-cell Immunoglobulin-like Receptors (KIR) interact with HLA class I molecules, and this interaction is peptide-dependent. The activating receptor KIR2DS4 enables NK cell degranulation following interaction with specific peptides presented within HLA-C*05. However, the mechanism underlying the differential NK cell response depending on a peptide remains poorly understood and lacks explanation based on the structure of ligand-receptor interaction. Using AlphaFold 3, we generated models of KIR2DS4-peptide-HLA-C*05 complexes to analyze the contact interfaces. We confirmed the substantial role of the aromatic ring in the 8th amino acid residue of peptide sequences in mediating interactions with KIR2DS4. Even with the same amino acid residue at position 8, different peptides exhibited variability in polar contacts with KIR2DS4. Our results may contribute to the prediction of KIR-HLA interactions and facilitate the identification of specific peptides capable of activating NK cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BIOCHEMISTRY MOSCOW SUPPLEMENT SERIES A-MEMBRANE AND CELL BIOLOGY
ISSN
1990-7478
e-ISSN
1990-7494
Volume of the periodical
19
Issue of the periodical within the volume
3
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
356-362
UT code for WoS article
001553163400009
EID of the result in the Scopus database
2-s2.0-105013571962