How Argonautes engage with their protein binding partners

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F25%3A00143660" target="_blank" >RIV/00216224:14740/25:00143660 - isvavai.cz</a>
Result on the web
<a href="https://argonautes.img.cas.cz/" target="_blank" >https://argonautes.img.cas.cz/</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
How Argonautes engage with their protein binding partners
Original language description
Argonaute proteins are central to small RNA-guided gene silencing and have long been known to associate with a variety of protein cofactors across pathways and organisms. However, only a limited number of these interactions have been directly validated, and high-resolution structural insights into how Argonautes engage with their protein partners–and how such interactions influence function–remain limited. In this talk, we will present our recent cryo-EM findings revealing two previously unrecognized modes of Argonaute-protein interaction, shedding light on how these contacts may modulate Argonaute conformation and activity.
Czech name
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Czech description
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Project
<a href="/en/project/EH22_008%2F0004575" target="_blank" >EH22_008/0004575: RNA for therapy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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