Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A90127%2F22%3A00133747" target="_blank" >RIV/00216224:90127/22:00133747 - isvavai.cz</a>
Result on the web
<a href="https://pubs.acs.org/doi/10.1021/acsami.2c11946" target="_blank" >https://pubs.acs.org/doi/10.1021/acsami.2c11946</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acsami.2c11946" target="_blank" >10.1021/acsami.2c11946</a>
Alternative languages
Result language
angličtina
Original language name
Stimuli-Responsive Membrane Anchor Peptide Nanofoils for Tunable Membrane Association and Lipid Bilayer Fusion
Original language description
Self-assembled peptide nanostructures with stimuli-responsive features are promising as functional materials. Despite extensive research efforts, water-soluble supramolecular constructs that can interact with lipid membranes in a controllable way are still challenging to achieve. Here, we have employed a short membrane anchor protein motif (GLFD) and coupled it to a spiropyran photoswitch. Under physiological conditions, these conjugates assemble into similar to 3.5 nm thick, foil-like peptide bilayer morphologies. Photo-isomerization from the closed spiro (SP) form to the open merocyanine (MC) form of the photoswitch triggers rearrangements within the foils. This results in substantial changes in their membrane-binding properties, which also varies sensitively to lipid composition, ranging from reversible nanofoil reformation to stepwise membrane adsorption. The formed peptide layers in the assembly are also able to attach to various liposomes with different surface charges, enabling the fusion of their lipid bilayers. Here, SP-to-MC conversion can be used both to trigger and to modulate the liposome fusion efficiency.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
21000 - Nano-technology
Result continuities
Project
—
Continuities
—
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
ACS APPLIED MATERIALS & INTERFACES
ISSN
1944-8244
e-ISSN
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Volume of the periodical
14
Issue of the periodical within the volume
50
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
55320-55331
UT code for WoS article
000894035600001
EID of the result in the Scopus database
2-s2.0-85143882788