Cerebrospinal fluid oligoclonal IgM test in routine practice: Comparison with quantitative assessment of intrathecal IgM synthesis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A90128%2F20%3A00140072" target="_blank" >RIV/00216224:90128/20:00140072 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17110/20:A21026QG RIV/00843989:_____/20:E0108434

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S0009898120302187?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0009898120302187?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2020.05.021" target="_blank" >10.1016/j.cca.2020.05.021</a>

Result language

angličtina

Original language name

Cerebrospinal fluid oligoclonal IgM test in routine practice: Comparison with quantitative assessment of intrathecal IgM synthesis

Original language description

Background: Intrathecal IgM synthesis demonstrated either as cerebrospinal fluid (CSF)-restricted oligoclonal (o-) IgM bands or calculated using various formulas has been linked to more aggressive multiple sclerosis (MS) course. However, the proportion of MS patients showing intrathecal IgM synthesis varies largely between studies. We aimed to explore the relation between different formulas and results of o-IgM, and to assess the frequency of o-IgM bands in an unselected series of samples. Methods: 432 samples were analyzed for o-IgM, o-IgG and quantitative measures of IgM and IgG synthesis. IgM index and formulas of Reiber, Auer and Ohman were compared to the result of the o-IgM test. Results: At the cut-off commonly used, the non-linear formulas for intrathecal synthesis were specific (&gt; 94%) but rather insensitive (&lt; 40% even at a cut-off of 4 CSF-restricted bands) compared to o-IgM. No significant difference was noted in the performance of different formulas. At a cut-off of 4 bands, 61% of MS patients, but none of the controls were positive for o-IgM. Conclusions: Formulas for intrathecal IgM synthesis are insensitive compared to o-IgM. We propose to evaluate samples with 2 or 3 extra-CSF IgM bands as borderline and only samples with 4 or more as definitely positive.

Czech name

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Czech description

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Type

J_ost - Miscellaneous article in a specialist periodical

CEP classification

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OECD FORD branch

30230 - Other clinical medicine subjects

Project

—

Continuities

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Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinica Chimica Acta

ISSN

0009-8981

e-ISSN

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Volume of the periodical

508

Issue of the periodical within the volume

NA

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

137-145

UT code for WoS article

000549228300021

EID of the result in the Scopus database

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