Utilization of HPLC for monitoring of less-known risk factors of atherosclerosis

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F06%3A00003176" target="_blank" >RIV/00216275:25310/06:00003176 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

čeština

Original language name

Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy

Original language description

Several clinical studies have indicated that high plasma concentration of the sulphur aminoacid homocysteine is an independent risk factor for origin and progress of atherosclerosis. Increased levels of total plasma homocysteine can be treated with vitamins B6, B12 and folic acid. The most frequent methods for determination of total plasma homocysteine are immunochemical and HPLC methods. We have chosen an ion-paired reversed-phase HPLC method with coulometric electrochemical detection, without time-consuming derivatization. Oxidation of LDL is important event in etherosclerosis. Reduced form of coenzyme Q10 protects LDL from oxidative damage. We have measured reduced and oxidized forms of coenzyme Q10 using HPLC with coulometric electrochemical detection too.

Czech name

Využití HPLC v monitorování méně známých rizikových faktorů aterosklerózy

Czech description

Several clinical studies have indicated that high plasma concentration of the sulphur aminoacid homocysteine is an independent risk factor for origin and progress of atherosclerosis. Increased levels of total plasma homocysteine can be treated with vitamins B6, B12 and folic acid. The most frequent methods for determination of total plasma homocysteine are immunochemical and HPLC methods. We have chosen an ion-paired reversed-phase HPLC method with coulometric electrochemical detection, without time-consuming derivatization. Oxidation of LDL is important event in etherosclerosis. Reduced form of coenzyme Q10 protects LDL from oxidative damage. We have measured reduced and oxidized forms of coenzyme Q10 using HPLC with coulometric electrochemical detection too.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CB - Analytical chemistry, separation

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

CHEMagazín

ISSN

1210-7409

e-ISSN

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Volume of the periodical

16

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

2

Pages from-to

8-9

UT code for WoS article

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EID of the result in the Scopus database

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