Miminizing the Effects of Multicollinearity in the Polynomial Regression of Age Relationships and Sex Differences in Serum Levels of Pregnelonone Sulfate in Healthy Subjects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F09%3A00008380" target="_blank" >RIV/00216275:25310/09:00008380 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Miminizing the Effects of Multicollinearity in the Polynomial Regression of Age Relationships and Sex Differences in Serum Levels of Pregnelonone Sulfate in Healthy Subjects

Original language description

Pregnenolone-sulfate (PregS) is known as a steroid conjugate positively modulating N-methyl-D-aspartate (NMDA) receptors on neuronal membranes. These receptors are responsible for permeability of calcium channels and activation of neuronal function. Neuroactivating effect of PregS is also exerted via noncompetitive negative modulation of GABAA receptors regulating the chloride influx. Recently, a penetrability of blood-brain barrier for PregS was found in rat, but some experiments being in agreement with this finding were reported even beforehand.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Chemistry and Laboratory Medicine

ISSN

1434-6621

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

4

Country of publishing house

DE - GERMANY

Number of pages

7

Pages from-to

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UT code for WoS article

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EID of the result in the Scopus database

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