The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data ,
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F10%3A39881671" target="_blank" >RIV/00216275:25310/10:39881671 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The thermodynamic dissociation constants of two drugs rasagiline base and rasagiline mesylate by the nonlinear regression and factor analysis of multiwavelength spectrophotometric pH-titration data ,
Original language description
The mixed dissociation constants of rasagiline-free base [N-propargyl-1-(R)aminoindan] and rasagiline mesylate [N-propargyl-1-(R)aminoindan] methansulfonate) at different ionic strengths I in the range of (0.01 and 0.4) mol . L-1 and at temperatures of (25 and 37) degrees C were determined with the use of two different multiwavelength and multivariate treatments of spectral data, SPECEIT32 and SQUAD(84), nonlinear regression analyses. Most indices always predict the correct number of components when thesignal-to-error ratio (SER) is higher than 10: for rasagiline base, pK(a)(T) = 7.12(1) at 25 degrees C and 7.01(1) at 37 degrees C; for rasagiline mesylate, pK(a)(T) = 7.07(1) at 25 degrees C and 7.16(1) at 37 degrees C, where the value in parentheses is the standard deviation in the last significant digit.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Chemical and Engineering Data
ISSN
0021-9568
e-ISSN
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Volume of the periodical
55
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
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UT code for WoS article
000280727300010
EID of the result in the Scopus database
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