Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F10%3A39882506" target="_blank" >RIV/00216275:25310/10:39882506 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Electrochemical Analysis of DNA: When, How and Why to Use Electroactive Labels and Indicators
Original language description
DNA possesses intrinsic electrochemical activity due to the presence of electrochemically reducible or oxidizable nucleobases and exhibits characteristic, structure-sensitive adsorption/desorption behavior at mercury or amalgam electrodes. Thus, label-free electrochemical DNA sensing is in principle possible, and especially in connection with mercury-based or carbon electrodes the intrinsic DNA electroactivity has been utilized to detect DNA damage. In other applications, such as sequence-specific DNA sensing, typing of single-nucleotide polymorphisms (SNP) etc., utilization of electroactive labels has appeared advantageous. We present several examples of using redox-active or enzymatic DNA tags in the detection of DNA damage, DNA hybridization and minisequencing of the SNP.
Czech name
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Czech description
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Project
<a href="/en/project/LC06035" target="_blank" >LC06035: Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Sborník přednášek mezinárodní odborné konference XXX. Moderní elektrochemické metody
ISBN
978-80-254-6710-7
ISSN
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e-ISSN
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Number of pages
5
Pages from-to
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Publisher name
BEST Servis
Place of publication
Ústí nad Labem
Event location
Jetřichovice
Event date
May 24, 2010
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000283050900010

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