Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39883426" target="_blank" >RIV/00216275:25310/11:39883426 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jct.2011.01.012" target="_blank" >http://dx.doi.org/10.1016/j.jct.2011.01.012</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jct.2011.01.012" target="_blank" >10.1016/j.jct.2011.01.012</a>

Result language
angličtina
Original language name
Determination of the thermodynamic dissociation constant of capecitabine using spectrophotometric and potentiometric titration data
Original language description
Capecitabine has been studied by a combined potentiometric and spectrophotometric titration at T = (298.15, 310.15) K at different ionic strengths. The thermodynamic dissociation constant was estimated by non-linear regression of (pK(a), I) data: pK(a)(T) = 8.97(1) at T = 298.15 K and pK(a)(T) = 8.74(0) at T = 310.15 K, where the figure in the brackets is the standard deviation in last significant digits. Thermodynamic parameters Delta H degrees/kJ.mol(-1) and Delta S degrees/J.K-1.mol(-1) have been determined from the temperature variation of thermodynamic dissociation constants. The value of enthalpy Delta H degrees = 33.9 kJ.mol(-1) shows the dissociation process is endothermic and the value of entropy Delta S degrees = -51.9J.K-1.mol(-1) indicatesthat the dissociation is not a spontaneous process.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
—

Project
<a href="/en/project/NS9831" target="_blank" >NS9831: Optimization of laboratory examinations in endocrinology using multivariate statistics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)