Effect of Substitution on the Antimycobacterial Activity of 2-(Subst. Benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F11%3A39891994" target="_blank" >RIV/00216275:25310/11:39891994 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1248/cpb.59.179" target="_blank" >http://dx.doi.org/10.1248/cpb.59.179</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1248/cpb.59.179" target="_blank" >10.1248/cpb.59.179</a>

Result language

angličtina

Original language name

Effect of Substitution on the Antimycobacterial Activity of 2-(Subst. Benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and

Original language description

A set of 1160 MIC values evaluating effect of substitution on the antimycobacterial activity of the previously published 2-(subst. benzyl)sulfanyl benzimidazoles, benzoxazoles, and benzothiazoles has been analyzed by the methods of multidimensional . Theantimycobacterial activity increased in the order of BTZ{BOZ~BIM{5 Me-BIM. The sensitivity of particular strains towards these compounds decreased in the order of M. kansasii 6509/96, M. avium My 330/88, M. kansasii My 235/80, and M. tuberculosis My 331/88. The log MIC values depended with a negative slope on the Hammett substituent constants sigma or molar refractions MR and, for the given set of substituents, were dominantly raised with increasing log P value and partially lowered with (log P)2 or sigma xlog delta P. The derivatives featuring high polarizability, low lipophilicity and electron-withdrawing subtituents showed the highest antimycobacterial activity.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/GA203%2F08%2F0208" target="_blank" >GA203/08/0208: Inorganic-organic hybrid materials based on metal organophosphonates</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chemical and Pharmaceutical Bulletin

ISSN

0009-2363

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

2

Country of publishing house

JP - JAPAN

Number of pages

6

Pages from-to

"179?184"

UT code for WoS article

000286863200006

EID of the result in the Scopus database

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