a-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39894592" target="_blank" >RIV/00216275:25310/12:39894592 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2478/s11532-012-0087-1" target="_blank" >http://dx.doi.org/10.2478/s11532-012-0087-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11532-012-0087-1" target="_blank" >10.2478/s11532-012-0087-1</a>

Result language
angličtina
Original language name
a-Amino acid-derived 2-phenylimidazoles with potential antimycobacterial activity
Original language description
alfa-Amino acid-derived 2-phenylimidazole derivatives were designed, synthesized, and further investigated as potential antimycobacterial agents. The synthesis of target imidazole derivatives involved the transformation of Cbz-protected alfa-amino acids(Ala, Val, Phe, Leu, iLe, and Pro) into alfa-diazoketones and alfa-bromoketones, respectively. Subsequent treatment of alfa-bromoketones with (4-nitro) benzamidine afforded imidazole derivatives bearing alfa-amino acid residue appended to the imidazole C4 and (4-nitro)phenyl ring in the position C2. Antimycobacterial activities of both series of compounds against M. tuberculosis, M. avium, and M. kansasii were screened and basic structure-activity relationships were further evaluated.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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