Voltammetric determination of leucovorin using silver solid amalgam electrode

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895237" target="_blank" >RIV/00216275:25310/12:39895237 - isvavai.cz</a>

Alternative codes found

RIV/61388955:_____/12:00375916

Result on the web

<a href="http://dx.doi.org/10.1016/j.electacta.2011.11.071" target="_blank" >http://dx.doi.org/10.1016/j.electacta.2011.11.071</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.electacta.2011.11.071" target="_blank" >10.1016/j.electacta.2011.11.071</a>

Result language

angličtina

Original language name

Voltammetric determination of leucovorin using silver solid amalgam electrode

Original language description

The voltammetric behavior of leucovorin (LV), as an important and stable reduced metabolite of folic acid, has been investigated on polished (p-AgSAE) and mercury meniscus modified (m-AgSAE) silver solid amalgam electrodes in this paper. LV, after its reverse electrochemical oxidation, can be reduced in two reduction steps in an acidic medium on both electrodes used. The first reduction peak (E-p = -400 mV) can be used for determination of LV. Differential Pulse Voltammetry (DPV) was applied for monitoring voltammetric behavior of LV on both working electrodes. Elimination voltammetry with linear scan was applied for elucidation of the reaction mechanisms. The limits of detection were calculated as 2.2 x 10(-8) mol L-1 (t(acc) = 60 s) for m-AgSAE and 5.0 x 10(-8) mol L-1 (t(acc) = 100 s) for p-AgSAE. The proposed method was applied for LV determination in the pharmaceutical preparation which has been commonly used during methotrexate therapy. (C) 2011 Published by Elsevier Ltd.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CG - Electrochemistry

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrochimica Acta

ISSN

0013-4686

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

January

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

375-383

UT code for WoS article

000300142100052

EID of the result in the Scopus database

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