Antibodies against Carbonic Anhydrase in Patients with Aplastic Anemia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39895323" target="_blank" >RIV/00216275:25310/12:39895323 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1159/000338826" target="_blank" >http://dx.doi.org/10.1159/000338826</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000338826" target="_blank" >10.1159/000338826</a>

Result language

angličtina

Original language name

Antibodies against Carbonic Anhydrase in Patients with Aplastic Anemia

Original language description

Antibodies against carbonic anhydrase (CA) have been detected in patients with an aplastic anemia (AA)-like syndrome after autologous stem cell transplantation. We analyzed sera of 53 bona fide AA patients before and after treatment with anti-thymocyte globulin (ATG) or bone marrow transplantation for the presence of anti-CA antibodies. Anti-CA antibodies were detected in 20 patients (38%) and were associated with older age at diagnosis of AA. Antibody-positive patients showed poor response to ATG treatment (complete response 14%) and inferior long-term survival (36% at 10 years), when compared to antibody-negative patients (complete response and 10-year survival both 64%). Two thirds of patients with antibodies at diagnosis of AA became antibody negative after treatment with ATG. Clearance of the antibody did not appear to be associated with hematological improvement. Antibodies against CA are detected frequently at diagnosis of AA, and their presence identifies a subset of patients w

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0021" target="_blank" >EE2.3.30.0021: Strenthening of Research and Development Teams at the University of Pardubice</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Acta Haematologica

ISSN

0001-5792

e-ISSN

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Volume of the periodical

128

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

5

Pages from-to

190-194

UT code for WoS article

000307875700011

EID of the result in the Scopus database

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