Biotransformation of Benzimidazole Anthelmintics in Reed (Phragmites australis) as a Potential Tool for their Detoxification in Environment

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896255" target="_blank" >RIV/00216275:25310/13:39896255 - isvavai.cz</a>
Alternative codes found
RIV/61389030:_____/13:00399919 RIV/00216208:11160/13:10144276
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0960852413010341" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0960852413010341</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.biortech.2013.06.105" target="_blank" >10.1016/j.biortech.2013.06.105</a>

Result language
angličtina
Original language name
Biotransformation of Benzimidazole Anthelmintics in Reed (Phragmites australis) as a Potential Tool for their Detoxification in Environment
Original language description
Benzimidazole anthelmintics, the drugs against parasitic worms, are widely used in human as well as veterinary medicine. Following excretion, these substances may persist in the environment and impact non-target organisms. In order to test phytoremediation as a possible tool for detoxification of anthelmintics in environment, the biotransformation pathways of albendazole (ABZ) and flubendazole (FLU) were studied in reed (Phragmites australis) in vitro. Reed cells were able to uptake and biotransform both anthelmintics. Ten ABZ metabolites and five FLU metabolites were found. Some atypical biotransformation reactions (formation of glucosylglucosides, acetylglucosides and xylosylglucosides), which have not been described previously, were identified. Based on the obtained results, the schemes of metabolic pathways of ABZ and FLU in reed were proposed. Most of ABZ and FLU metabolites can be considered as anthelmintically less active; therefore uptake and biotransformation of these anthelmi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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