Inhibitory effect of carbamates in two types of cholinesterases

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F13%3A39896738" target="_blank" >RIV/00216275:25310/13:39896738 - isvavai.cz</a>
Result on the web
—
DOI - Digital Object Identifier
—

Result language
angličtina
Original language name
Inhibitory effect of carbamates in two types of cholinesterases
Original language description
Inhibitory effect of substituted 3-(diethylaminophenyl) phenyl carbamates in two types of cholineserases (acetylcholinesterase and butyrylcholinesterase) was determined. Inhibiting effectiveness was described by the value of IC50 (50% inhibitory concentration). Modified spectrophotometric Ellman's method was used. Two types of choline esters were used as substrates for cholinesterases. It was proved, that chosen carbamates are quite effective inhibitors of cholinesterases. The most effective inhibitor of acetylcholinesterase is 3-(diethylaminophenyl) phenyl carbamate with the value of IC50 = 1.52 uM and the most effective inhibitor of butyrylcholinesterase is 3-(diethylaminophenyl) (3-nitrophenyl) carbamate with the value of IC50 = 1.70 uM.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
—
Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical
Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology
ISSN
1211-5541
e-ISSN
—
Volume of the periodical
19
Issue of the periodical within the volume
prosinec
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
8
Pages from-to
49-56
UT code for WoS article
—
EID of the result in the Scopus database
—

Similar results(10)