Henry reaction catalyzed by recoverable enantioselective catalysts based on copper(II) complexes of alfa-methoxypoly (ethylene glycol)-b-poly(L-glutamic acid) and imidazolidine-4-one ligands

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39897719" target="_blank" >RIV/00216275:25310/14:39897719 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tetasy.2014.01.001" target="_blank" >http://dx.doi.org/10.1016/j.tetasy.2014.01.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetasy.2014.01.001" target="_blank" >10.1016/j.tetasy.2014.01.001</a>

Result language
angličtina
Original language name
Henry reaction catalyzed by recoverable enantioselective catalysts based on copper(II) complexes of alfa-methoxypoly (ethylene glycol)-b-poly(L-glutamic acid) and imidazolidine-4-one ligands
Original language description
Herein we describe the preparation and characterization of a recoverable catalyst for a Henry reaction based on a Cu(II) complex of block copolymer a-methoxypoly(ethylene glycol)-b-poly(L-glutamic acid) with (2R,5S)- or (2S,5R)-5-isopropyl-5-methyl-2-(pyridine-2-yl)imidazolidine-4-one. The reactions of substituted aldehydes with nitromethane catalyzed by these catalysts proceed with high chemical yield (70-98%) and with high enantioselectivity (61-92% ee). The reaction mixture is in the form of a colloid system and is formed by self-organized aggregates of the catalysts with average hydrodynamic particle size of 189 +- 3 nm (DLS). After sevenfold recycling, the catalyst exhibited no decrease in the enantioselectivity and only a slight decrease (ca. 18%) in the yield for the Henry reaction of nitromethane with 2-methoxybenzaldehyde.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/GAP106%2F11%2F0058" target="_blank" >GAP106/11/0058: Phosgene Derivatives for Nanotechnologies</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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