PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898116" target="_blank" >RIV/00216275:25310/14:39898116 - isvavai.cz</a>

Result on the web

<a href="http://download.springer.com/static/pdf/98/art%253A10.1007%252Fs00125-014-3310-0.pdf?auth66=1418981818_714d2c604725b6077692eb98fc804e20&ext=.pdf" target="_blank" >http://download.springer.com/static/pdf/98/art%253A10.1007%252Fs00125-014-3310-0.pdf?auth66=1418981818_714d2c604725b6077692eb98fc804e20&ext=.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00125-014-3310-0" target="_blank" >10.1007/s00125-014-3310-0</a>

Result language

angličtina

Original language name

PNPLA3 variant I148M is associated with altered hepatic lipid composition in humans

Original language description

Aims/hypothesis The common sequence variant I148M of the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) is associated with increased hepatic triacylglycerol (TAG) content, but not with insulin resistance, in humans. The PNPLA3(I148M) variant was previously reported to alter the specificity of the encoded enzyme and subsequently affect lipid composition. Methods We analysed the fatty acid composition of five lipid fractions from liver tissue samples from 52 individuals, including 19carriers of the minor PNPLA3(I148M) variant. Results PNPLA3(I148M) was associated with a strong increase (1.75-fold) in liver TAGs, but with no change in other lipid fractions. PNPLA3(I148M) minor allele carriers had an increased n-3 polyunsaturated fatty acid (PUFA) alpha-linolenic acid content and reductions in several n-6 PUFAs in the liver TAG fraction. Furthermore, there was a strong inverse correlation between n-6 PUFA and TAG content independent of PNPLA3 genotype. In a multivari

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Diabetologia

ISSN

0012-186X

e-ISSN

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Volume of the periodical

57

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

2103-2107

UT code for WoS article

000341708900012

EID of the result in the Scopus database

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