Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898170" target="_blank" >RIV/00216275:25310/14:39898170 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jpba.2013.08.053" target="_blank" >http://dx.doi.org/10.1016/j.jpba.2013.08.053</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2013.08.053" target="_blank" >10.1016/j.jpba.2013.08.053</a>
Alternative languages
Result language
angličtina
Original language name
Identification of Combined Conjugation of Nabumetone Phase I Metabolites with Glucuronic Acid nad Glycine in Minipig Biotransformation Using Coupling High-performance Liquid Chromatography with Electrospray Ionization Mass Spectrometry
Original language description
High-performance liquid chromatography (HPLC) coupled with electrospray ionization mass spectrometry (ESI-MS) was applied for the analysis of nabumetone metabolites during the biotransformation in minipigs. In addition to known phase I metabolites, the identification of phase II metabolites was achieved on the basis of their full-scan mass spectra and subsequent MSn analysis using both positive-ion and negative-ion ESI mode. Some phase I metabolites are conjugated with both glucuronide acid and glycine,which is quite unusual type of phase II metabolite not presented so far for nabumetone. These metabolites were found in small intestine content, but they were absent in minipigs urine.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical and Biomedical Analysis
ISSN
0731-7085
e-ISSN
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Volume of the periodical
88
Issue of the periodical within the volume
January
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
221-224
UT code for WoS article
000329532800031
EID of the result in the Scopus database
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