Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898208" target="_blank" >RIV/00216275:25310/14:39898208 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/14:10281582
Result on the web
<a href="http://dx.doi.org/10.1002/dta.1630" target="_blank" >http://dx.doi.org/10.1002/dta.1630</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/dta.1630" target="_blank" >10.1002/dta.1630</a>
Alternative languages
Result language
angličtina
Original language name
Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus)
Original language description
Monepantel (MOP) is a new anthelmintic drug intended for the treatment and control of gastrointestinal roundworms (nematodes) infection and associated disease in sheep. The aim of our study was to find out metabolic pathways of MOP in sheep in vivo and in its parasite Haemonchus contortus ex vivo. MOP biotransformation in two H. contortus strains with different sensitivity to anthelmintics was also compared. Ultra high-performance liquid chromatography with tandem mass spectrometry (UHPLC-MS/MS) technique is used for the identification of MOP metabolites in ovine urine, faeces, and nematodes. MOP biotransformation study in sheep in vivo led to the identification of 13 MOP metabolites; 7 of them have not been described previously in in vitro study. Thestudy of MOP biotransformation in H. contorus ex vivo reveals four MOP metabolites. The nitrile hydrolysis as a new biotransformation pathway in helminths ex vivo is reported here for the first time. Unlike sheep, H. contorus nematodes ar
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
GJ - Diseases and animal vermin, veterinary medicine
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP502%2F10%2F0217" target="_blank" >GAP502/10/0217: Drug-resistance development in helminths - possible mechanisms and defense</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Drug Testing and Analysis
ISSN
1942-7603
e-ISSN
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Volume of the periodical
6
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
"1055?1062"
UT code for WoS article
000343814800011
EID of the result in the Scopus database
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