Bioinorganic chemistry of vanadocene dichloride

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39899624" target="_blank" >RIV/00216275:25310/15:39899624 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ica.2015.08.008" target="_blank" >http://dx.doi.org/10.1016/j.ica.2015.08.008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ica.2015.08.008" target="_blank" >10.1016/j.ica.2015.08.008</a>

Result language
angličtina
Original language name
Bioinorganic chemistry of vanadocene dichloride
Original language description
This review article summarizes the development in bioinorganic chemistry of vanadocene dichloride and its derivatives. It is focused mainly on studies related with biological activity appearing in past four decades, after the antitumor activity of bent metallocenes was discovered by Petra Kopf-Maier and Hartmut Kopf. The first part deals with the unique hydrolytic chemistry of vanadocene dichloride and the reactivity with biologically relevant molecules, necessary for understanding of its antitumor effect on the molecular level. The second part summarizes the results of in vitro and in vivo biological assays. It covers not only the experiments related with antitumor activity but also a series of studies focused on the spermicidal properties with uniquemechanism of action. A special attention is given to structure-activity studies on modified vanadocene compounds.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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