Henry reaction catalyzed by new series of imidazolidine-4-one Cu-complexes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39899686" target="_blank" >RIV/00216275:25310/15:39899686 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tetasy.2015.01.001" target="_blank" >http://dx.doi.org/10.1016/j.tetasy.2015.01.001</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetasy.2015.01.001" target="_blank" >10.1016/j.tetasy.2015.01.001</a>

Result language
angličtina
Original language name
Henry reaction catalyzed by new series of imidazolidine-4-one Cu-complexes
Original language description
A series of 5-tert-butyl-2-(pyridine-2-yl)imidazolidine-4-ones have been prepared and their Cu(II) complexes studied as enantioselective catalysts of the asymmetric Henry reaction of various aldehydes with nitromethane. It was found that these compoundswere effective catalysts for this reaction, with enantiomeric excesses being as high as 97%. The enantioselectivities of individual derivatives were different and depended on the substituents attached to stereogenic centers and the configuration of imidazolidine-4-one cycle. High enantiomeric excesses were obtained irrespective of the solvent used. The most effective derivative was chosen for preparation of the key intermediate for Salmeterol medical drug and an enantiomeric excess of 92% was obtained.
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
—

Project
<a href="/en/project/GA14-00925S" target="_blank" >GA14-00925S: Immobilized Enantioselective Catalysts</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)