Synthesis, structural characterization, antimicrobial and antifungal activity of substituted 6-?uorobenzo[d]thiazole amides

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39899908" target="_blank" >RIV/00216275:25310/15:39899908 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1007/s00044-015-1410-0" target="_blank" >http://dx.doi.org/10.1007/s00044-015-1410-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00044-015-1410-0" target="_blank" >10.1007/s00044-015-1410-0</a>

Result language

angličtina

Original language name

Synthesis, structural characterization, antimicrobial and antifungal activity of substituted 6-?uorobenzo[d]thiazole amides

Original language description

A series of novel 1-[(1R)-1-(6-?uoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl amides was synthesized by the condensation reaction of (1R)-1-(6-?uoro-1,3-benzothiazol-2-yl)ethanamine with substituted benzoyl chlorides under mild conditions. Theirstructures were con?rmed by 1H NMR, 13C NMR and 19F NMR spectra, elemental analyses and in three cases also by single-crystal X-ray diffraction techniques. The optical activities were con?rmed by optical rotation measurements. All the synthesized compounds were screened for antibacterial and antifungal activity against a variety of bacterial and fungal strains. Some of the compounds reveal antibacterial and antifungal activity comparable or slightly better to that of chloramphenicol, cefoperazone and amphotericin B used as medicinal standards.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal Chemistry Research

ISSN

1054-2523

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

2015

Country of publishing house

US - UNITED STATES

Number of pages

11

Pages from-to

3660-3670

UT code for WoS article

000360508300006

EID of the result in the Scopus database

—