Enantioselective Aerobic Oxidative C(sp(3))-H Olefination of Amines via Cooperative Photoredox and Asymmetric Catalysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901368" target="_blank" >RIV/00216275:25310/16:39901368 - isvavai.cz</a>
Result on the web
<a href="http://pubs.acs.org/doi/ipdf/10.1021/acscatal.6b00846" target="_blank" >http://pubs.acs.org/doi/ipdf/10.1021/acscatal.6b00846</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/acscatal.6b00846" target="_blank" >10.1021/acscatal.6b00846</a>

Result language
angličtina
Original language name
Enantioselective Aerobic Oxidative C(sp(3))-H Olefination of Amines via Cooperative Photoredox and Asymmetric Catalysis
Original language description
A cooperative photoredox and asymmetric catalysis for the enantioselective aerobic oxidative C(sp(3))-H olefination of tetrahydro-beta-carbolines (THCs) is reported. This method, which is also effective for tetrahydroisoquinolines (THIQs), features a triple-catalyst strategy, involving a dicyanopyrazine-derived chromophore (DPZ) as the metal-free photoredox catalyst, a chiral Lewis base catalyst, and an inorganic salt cocatalyst. The current protocol provides straightforward access to a series of valuable a-substituted THCs and THIQs in high yields with excellent regio- and enantioselectivities (up to 95% ee).
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CC - Organic chemistry
OECD FORD branch
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Project
<a href="/en/project/GA13-01061S" target="_blank" >GA13-01061S: Organic Push-Pull Molecules: Versatile Materials for Optoelectronics</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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