Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901615" target="_blank" >RIV/00216275:25310/16:39901615 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/16:43874210

Result on the web

<a href="http://dx.doi.org/10.1016/j.jab.2016.01.005" target="_blank" >http://dx.doi.org/10.1016/j.jab.2016.01.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jab.2016.01.005" target="_blank" >10.1016/j.jab.2016.01.005</a>

Result language

angličtina

Original language name

Antimicrobial effect of salicylamide derivatives against intestinal sulfate-reducing bacteria

Original language description

Sulfate-reducing bacteria (SRB) are most likely involved in both the initiation and maintenance of inflammatory bowel disease (IBD); unfortunately present antibacterial chemotherapeutics used in the treatment of IBD have been ineffective. Thus, the antimicrobial activity of salicylamide derivatives against two different genera of intestinal SRB, Desulfovibrio and Desulfomicrobium, was investigated. Six 2-(phenylcarbamoyl) phenyl N-[(benzyloxy)carbonyl] alkanoates and three 2-hydroxy-N-[(2S)-1-oxo-1-(phenylamino)alkan-2-yl]benzamides showed MIC values in the range from 0.22 to 0.35 mu M against Desulfovibrio piger Vib-7 and in the range from 0.27 to 8.52 mu M against Desulfomicrobium sp. Rod-9, while MIC values of ciprofloxacin were 41.2 mu M and 39.3 mu M. The highest potency against the two strains was observed for 4-chloro-N-{(2S)-1-[(3,4-dichlorophenyl)amino]-3-methyl-1-oxobutan-2-yl}-2-hydroxybenzamide (MIC 0.22 mu M and 0.27 mu M). 4-Chloro-2-[(4-nitrophenyl) carbamoyl]phenyl (2S)-2-{[(benzyloxy)carbonyl]amino}-3-methylbutanoate showed high activity against D. piger Vib-7 (MIC = 0.26 mu M), while 4-chloro-2-[(4-methylphenyl)carbamoyl]phenyl (2S)-2-[( tert-butoxycarbonyl)amino]-3-(1H-indol-2-yl) propanoate expressed high activity against Desulfomicrobium sp. Rod-9 (MIC = 0.31 mu M). Structure-activity relationships are discussed.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CC - Organic chemistry

OECD FORD branch

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Project

<a href="/en/project/EE2.3.30.0053" target="_blank" >EE2.3.30.0053: Pharmaco-toxicological evaluation of newly synthesized (isolated) compounds as an integration tool for pre-clinical disciplines at VFU Brno</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-021X

e-ISSN

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Volume of the periodical

14

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

125-130

UT code for WoS article

000373608500007

EID of the result in the Scopus database

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