A perspective combination of quantum dots and silica nanoparticles for bioconjugation with antibodies used in immunosensors for detection of human alpha-fetoprotein
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39910662" target="_blank" >RIV/00216275:25310/17:39910662 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
A perspective combination of quantum dots and silica nanoparticles for bioconjugation with antibodies used in immunosensors for detection of human alpha-fetoprotein
Original language description
The combination of quantum dots (QDs) with silica nanoparticles (SiNPs) as promising signal-generating label of antibodies used in electrochemical immunosensor is described. QDs-modified silica nanoparticles were conjugated with specific antibodies targeted to alpha-fetoprotein (AFP) to a creation of anti-AFP-SiNPs-QDs IgG conjugate for subsequent exploitation in quantum dot-linked immunosorbent assay (QLISA). Square wave anodic stripping voltammetry (SWASV) on mercury or bismuth film modified carbon screen-printed three-electrode sensors was used as a detection method. Insertion of nanoparticles to this system led to the achievement of higher current responses compare to results obtained with QDs only. Therefore, the sensitivity of complete immunoassay could be significantly improved.
Czech name
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Czech description
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Classification
Type
D - Article in proceedings
CEP classification
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OECD FORD branch
10620 - Other biological topics
Result continuities
Project
<a href="/en/project/GA15-16549S" target="_blank" >GA15-16549S: Development of ultrasensitive magneto-immunoassay based on quantum dots/antibody probes for simultaneous electrochemical detection of cancer markers.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
XXXVII. Moderní elektrochemické metody : sborník přednášek
ISBN
978-80-905221-5-2
ISSN
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e-ISSN
neuvedeno
Number of pages
5
Pages from-to
108-112
Publisher name
BEST Servis
Place of publication
Ústí nad Labem
Event location
Jetřichovice
Event date
May 15, 2017
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
000432424300024