Overlapping pKa of the multiprotic hemostyptic Eltrombopag using UV/VIS multiwavelength spectroscopy and potentiometry
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39910667" target="_blank" >RIV/00216275:25310/17:39910667 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25530/17:39910667
Result on the web
<a href="http://dx.doi.org/10.1007/s10953-017-0682-z" target="_blank" >http://dx.doi.org/10.1007/s10953-017-0682-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10953-017-0682-z" target="_blank" >10.1007/s10953-017-0682-z</a>
Alternative languages
Result language
angličtina
Original language name
Overlapping pKa of the multiprotic hemostyptic Eltrombopag using UV/VIS multiwavelength spectroscopy and potentiometry
Original language description
pH-potentiometric and WApH-spectrophotometric titrations of the multiprotic hemostyptic Eltrombopag for dissociation constants determination were compared. Hemostyptic and hemostatic Eltrombopag treats low blood platelet counts in adults with chronic immune idiopathic thrombocytopenia ITP. Eltrombopag exhibits five protonatable sites in a pH range of 2 to 10, where only two pK are well separated (ΔpK > 3), while the other three are near dissociation constants of overlapping equilibria. According to MARVIN prediction, in the neutral medium Eltrombopag occurs in the slightly water soluble form LH3 that can be protonated to the soluble species LH4 and LH5 The molecule LH3 can be dissociated to still difficultly soluble species LH2, LH and L. Due to limited solubility of Eltrombopag above pH 9.5 the protonation was studied up to pH 10. Five dissociation constants can be reliably determined with REACTLAB and SQUAD84 leading to the same value. From a dependence on ionic strength the thermodynamic dissociation constants were estimated at 25°C: pKa1T = 2.69, pKa2T = 6.97, pKa3T = 7.13, pKa4T = 7.65, pKa5T = 8.30. Since pH above 10 and pH down 5 occurs in a titrated solution the very fine precipitate of Eltrombopag which is initially forming a slight opalescence, this part of the potentiometric titration curve pH over 9 and pH below 5 was not taken into regression analysis to estimate pKa2 = 6.53(01), pKa3 = 7.60(04), pKa4 = 9.62(59), pKa5 = 10.55(340) at 25°C with ESAB and HYPERQUAD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Solution Chemistry
ISSN
0095-9782
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
24
Pages from-to
2014-2037
UT code for WoS article
000415208600005
EID of the result in the Scopus database
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