Novel synthetic approach to alfaprostol key intermediates via Stille coupling with an alkyne

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39911001" target="_blank" >RIV/00216275:25310/17:39911001 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.tetlet.2017.04.091" target="_blank" >http://dx.doi.org/10.1016/j.tetlet.2017.04.091</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tetlet.2017.04.091" target="_blank" >10.1016/j.tetlet.2017.04.091</a>

Result language
angličtina
Original language name
Novel synthetic approach to alfaprostol key intermediates via Stille coupling with an alkyne
Original language description
Novel intermediates based on the Corey skeleton for preparation of the omega-chain of non-halogenated unnatural prostaglandin analogues containing a triple bond at position 13-14 (PG numbering) were synthesized. The utilization of a novel synthetic approach towards a new tin intermediate, and subsequent Stille coupling opens up new possibilities for preparing these important pharmaceutical intermediates.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20501 - Materials engineering

Project
<a href="/en/project/TA03010819" target="_blank" >TA03010819: The Development of Technology for non-halogenated Veterinary Prostaglandins and their Intermediates.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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