Voltammetric Analysis of Disulfiram in Pharmaceuticals with a Cyclic Renewable Silver Amalgam Film Electrode
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F17%3A39911332" target="_blank" >RIV/00216275:25310/17:39911332 - isvavai.cz</a>
Result on the web
<a href="http://journals.tubitak.gov.tr/chem/issues/kim-17-41-1/kim-41-1-10-1603-70.pdf" target="_blank" >http://journals.tubitak.gov.tr/chem/issues/kim-17-41-1/kim-41-1-10-1603-70.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3906/kim-1603-70" target="_blank" >10.3906/kim-1603-70</a>
Alternative languages
Result language
angličtina
Original language name
Voltammetric Analysis of Disulfiram in Pharmaceuticals with a Cyclic Renewable Silver Amalgam Film Electrode
Original language description
Electrochemical properties of disulfiram, representative of highly significant bioactive compounds, were studied with a cyclic renewable silver amalgam film electrode (Hg(Ag)FE) using square wave cathodic stripping voltammetry (SWCSV). The influence of various factors such as pH, buffer concentration, buffer composition, and SWCSV parameters on current response was investigated. The optimum results in terms of signal shape and intensity were recorded in Britton Robinson buffer (pH 7.5) at 0.5 V versus Ag/AgCl/3 mol L-1 KCl. An elaborated electroanalytical procedure was used to determine disulfiram at the Hg(Ag)FE in the concentration range from 0.05 to 5.00 mu M. Precision, repeatability, and accuracy of the method as well as the influence of possible interferences were ascertained. The detection and quantification limits were 11 nM and 37 nM, respectively. The applicability of the developed method was tested in the determination of disulfiram in the commercial formulation Anticol. Thin-layer chromatography with image processing software was used to validate the accuracy of the method.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Turkish Journal of Chemistry
ISSN
1300-0527
e-ISSN
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Volume of the periodical
41
Issue of the periodical within the volume
1
Country of publishing house
TR - TURKEY
Number of pages
9
Pages from-to
116-124
UT code for WoS article
000395861400010
EID of the result in the Scopus database
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