Amorphous Enzalutamide - Non-isothermal recrystallization kinetics and thermal stability

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39913353" target="_blank" >RIV/00216275:25310/18:39913353 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.tca.2018.05.020" target="_blank" >http://dx.doi.org/10.1016/j.tca.2018.05.020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tca.2018.05.020" target="_blank" >10.1016/j.tca.2018.05.020</a>

Result language

angličtina

Original language name

Amorphous Enzalutamide - Non-isothermal recrystallization kinetics and thermal stability

Original language description

Recrystallization kinetics of amorphous Enzalutamide (two batches prepared by hot-melt extrusion and thermal evaporation of the solvent) was studied by differential scanning calorimetry. The preparation route was found to have significant effect on material thermal stability and initial degree of crystallinity - solvent evaporation led to formation of partially crystalline matrix with residual solvent content causing plasticization and the ongoing thermally induced crystallization was largely accelerated. Thermal recrystallization of both Enzalutamide batches led to a similar polymorphic form. The recrystallization kinetics was evaluated by means of modified multivariate kinetic analysis and described in terms of the autocatalytic gestak-Berggren and the nth order autocatalytic reaction models. The recrystallization kinetics were found to be dependent on applied heating rate, gradually shifting from the nucleation-growth kinetics to the autocatalyzed 0th order kinetics (with the effective order of reaction changing from 1 to 0.2). The autocatalytic Sestak-Berggren model appears to be more suitable for predictions of the Enzalutamide recrystallization behavior due to the constancy of the autocatalytic term (M = 0.55) with regard to the experimental conditions. In addition, the kinetic predictions of crystallization in pharmaceuticals were discussed in general based on theoretical simulations - importance of the aspects influencing the kinetic predictions was demonstrated.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10403 - Physical chemistry

Project

<a href="/en/project/GA17-11753S" target="_blank" >GA17-11753S: Kinetic analysis of complex physico-chemical processes</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Thermochimica Acta

ISSN

0040-6031

e-ISSN

—

Volume of the periodical

665

Issue of the periodical within the volume

July

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

134-141

UT code for WoS article

000437372400017

EID of the result in the Scopus database

2-s2.0-85047544744