Contribution to the rheological testing of pharmaceutical semisolids

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39913396" target="_blank" >RIV/00216275:25310/18:39913396 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11160/19:10368067

Result on the web

<a href="https://www.tandfonline.com/doi/pdf/10.1080/10837450.2018.1425432?redirect=1" target="_blank" >https://www.tandfonline.com/doi/pdf/10.1080/10837450.2018.1425432?redirect=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10837450.2018.1425432" target="_blank" >10.1080/10837450.2018.1425432</a>

Result language

angličtina

Original language name

Contribution to the rheological testing of pharmaceutical semisolids

Original language description

Rheological behaviour of pharmaceutical semisolid preparations significantly affects manufacturing pro- cess, administration, stability, homogeneity of incorporated drug, accuracy of dosing, adhesion in the place of application, drug release, and resulting therapeutic effect of the product. We performed test of consistency by penetrometry, rotational, oscillation and creep tests, and squeeze and tack tests of model samples to introduce methods suitable for characterization and comparison of semisolids in practice. Penetrometry is a simple method allowing sorting the semisolids to low and high stress-resistant materials but deficient for rheological characterization of semisolids. Value of yield stress, generally considered to be appropriate feature of semisolids, is significantly influenced by the method of testing and the way of evaluation. The hysteresis loops of model semisolids revealed incomplete thixotropy, therefore, three-step thixotropy test was employed. Semisolids showed nonlinear response in the creep phase of tests and par- tial recovery of structure by storing energy in the recovery phase. Squeeze and tack tests seem to be con- venient ways for comparison of semisolids. Our study can contribute to a better understanding of different flow behaviour of semisolids given by different physicochemical properties of excipients and can bring useful approaches to evaluation and comparison of semisolids in practice.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30104 - Pharmacology and pharmacy

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmaceutical Development and Technology

ISSN

1083-7450

e-ISSN

—

Volume of the periodical

24

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

80-88

UT code for WoS article

000457023300008

EID of the result in the Scopus database

2-s2.0-85040966071