Multifunctional Block Copolymers for Simultaneous Solubilization of Poorly Water-Soluble Cholesterol and Hydroxyapatite Crystals
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39914576" target="_blank" >RIV/00216275:25310/19:39914576 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201808331" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/adfm.201808331</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/adfm.201808331" target="_blank" >10.1002/adfm.201808331</a>
Alternative languages
Result language
angličtina
Original language name
Multifunctional Block Copolymers for Simultaneous Solubilization of Poorly Water-Soluble Cholesterol and Hydroxyapatite Crystals
Original language description
The solubilization of targeted compounds represents key criteria in the sophisticated field of medical chemistry but also in technical applications like scale removal. Especially, the simultaneous dissolution of two chemically different compounds remains challenging. Herein, macromolecular solubilizers are introduced for the simultaneous dissolution and encapsulation of poorly water-soluble cholesterol and hydroxyapatite. The peptide-based, amphiphilic block copolymers possess physicochemically disparate segments combined in one polymer chain as binding sites for hydrophobic as well as ionic materials. Small polymer libraries are synthesized and screened for structure-property relationships. Complementary analytical techniques suggest polymeric self-assembly into spherical adaptive nanoparticles with the fundamental ability to passively absorb significant amounts of hydrophobic cholesterol up to 33 wt%. Furthermore, the additional incorporation of acidic domains enables the simultaneous dissolution of hydrophobic compounds and mineral phases such as hydroxyapatite. Ultimately, those nontoxic block copolymers can be used to solubilize and absorb other lipophilic and ionic compounds such as Sudan III dye and calcium ions. Such multifunctional nanomaterials have a wide range of direct application for simultaneous dissolution or delivery of hydrophobic molecules and cations resp. minerals for instance in the field of atherosclerosis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10404 - Polymer science
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advanced Functional Materials
ISSN
1616-301X
e-ISSN
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Volume of the periodical
29
Issue of the periodical within the volume
19
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
1808331
UT code for WoS article
000471333600010
EID of the result in the Scopus database
2-s2.0-85061232913