A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39915141" target="_blank" >RIV/00216275:25310/19:39915141 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.jpba.2019.06.026" target="_blank" >https://doi.org/10.1016/j.jpba.2019.06.026</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2019.06.026" target="_blank" >10.1016/j.jpba.2019.06.026</a>
Alternative languages
Result language
angličtina
Original language name
A new sensing platform based on NH2fMWCNTs for the determination of antiarrhythmic drug Propafenone in pharmaceutical dosage forms
Original language description
A novel sensor based on a modification of glassy carbon electrode (GCE) with NH2-functionalized multi walled carbon nano-tubes (NH(2)fMWCNTs) is reported and its applicability to the electrochemical sensing of Propafenone (PPF) demonstrated. The electrochemical catalytic activity was also utilized as a sensitive detection method for the investigation of the detailed redox mechanism of PFF using cyclic and and differential pulse voltammetry. The surface morphology of the sensor was investigated by SEM armed with EDX probe. Electrochemical impedance spectroscopy was employed as well to define the electron transfer capability of modified and bare electrodes. Key experimental and instrumental conditions related to electrochemical determination by cyclic, differential pulse, and square wave voltammetry, such as amount of modifier, pH, scan rate, accumulation time and potential were studied and optimized. The results have shown a significant enhancement of the peak current after modifying the electrode; the calibration curves of PPF offering good linearity from 0.1 to 10 mu M, limit of quantification (LOQ) being 0.03 mu M and limit of detection (LOD) 0.01 mu M, both when using DPV technique. The proposed sensor was successfully applied to the determination of PFF in dosage form without any special purification, separation or pre-treatment steps. The results of analyses obtained with the proposed sensor were satisfactory and fully statistically relevant. (C) 2019 Elsevier B.V. All rights reserved.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical and Biomedical Analysis
ISSN
0731-7085
e-ISSN
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Volume of the periodical
174
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
534-540
UT code for WoS article
000479328000062
EID of the result in the Scopus database
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