Determination of acid dissociation constants, enthalpy, entropy andGibbs free energy of the baricitinib by the UV-metric and pH-metricanalysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F20%3A39916312" target="_blank" >RIV/00216275:25310/20:39916312 - isvavai.cz</a>
Alternative codes found
RIV/00216275:25530/20:39916312
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S0731708520314187?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0731708520314187?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jpba.2020.113532" target="_blank" >10.1016/j.jpba.2020.113532</a>
Alternative languages
Result language
angličtina
Original language name
Determination of acid dissociation constants, enthalpy, entropy andGibbs free energy of the baricitinib by the UV-metric and pH-metricanalysis
Original language description
Baricitinib is a drug used for the treatment of rheumatoid arthritis. It is a selective and reversible inhibitorof Janus kinases 1 and 2, which play an important role in signalling the pro-inflammatory pathwayactivated in autoimmune disorders such as rheumatoid arthritis. The pH-spectrophotometric and pH-potentiometric titrations allowed the measurement of three or four successive dissociation constantsof Baricitinib. Baricitinib neutral LH2molecule was able to protonate into two soluble cations LH42+,LH3+and dissociate into two soluble anions LH−and L2-in pure water. The graph of molar absorptioncoefficients of differently protonated species versus wavelength indicated that the spectra L, LH, LH2were the nearly the same for these species and that the spectra LH4and LH3were also similar. In thepH range from 2–13, four pKa´s of spectra analysis were reliably estimated by REACTLAB at I =0.0020 mol.dm-3values pKTa1= 3.07, pKTa2= 3.87, pKTa3= 6.27, pKTa4= 12.78 at 25◦C and pKTa1= 3.00, pKTa2= 3.79,pKTa3= 6.12, pKTa4= 12.75 at 37◦C. Potentiometric pH-titration analysis for a higher concentration of 1× 10-3mol. dm-3estimated with ESAB at I =0.0001 mol. dm-3values pKTa1= 3.69, pKTa2= 3.81, pKTa3=4.73 at 25◦C and pKTa1= 3.62, pKTa2= 3.73, pKTa3= 4.43 at 37◦C. Molar enthalpy H◦, molar entropy S◦and Gibbs free energy G◦were calculated from the spectra using a dependence ln K to 1/T.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10406 - Analytical chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Pharmaceutical and Biomedical Analysis
ISSN
0731-7085
e-ISSN
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Volume of the periodical
191
Issue of the periodical within the volume
November
Country of publishing house
US - UNITED STATES
Number of pages
11
Pages from-to
113532
UT code for WoS article
000579528000006
EID of the result in the Scopus database
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