Indomethacin: The Interplay between Structural Relaxation, Viscous Flow and Crystal Growth
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F22%3A39919524" target="_blank" >RIV/00216275:25310/22:39919524 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/1420-3049/27/17/5668" target="_blank" >https://www.mdpi.com/1420-3049/27/17/5668</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/molecules27175668" target="_blank" >10.3390/molecules27175668</a>
Alternative languages
Result language
angličtina
Original language name
Indomethacin: The Interplay between Structural Relaxation, Viscous Flow and Crystal Growth
Original language description
Non-isothermal differential scanning calorimetry (DSC) was used to study the influences of particle size (d(aver)) and heating rate (q(+)) on the structural relaxation, crystal growth and decomposition kinetics of amorphous indomethacin. The structural relaxation and decomposition processes exhibited d(aver)-independent kinetics, with the q(+) dependences based on the apparent activation energies of 342 and 106 kJ center dot mol(-1), respectively. The DSC-measured crystal growth kinetics played a dominant role in the nucleation throughout the total macroscopic amorphous-to-crystalline transformation: the change from the zero-order to the autocatalytic mechanism with increasing q(+), the significant alteration of kinetics, with the storage below the glass transition temperature, and the accelerated crystallization due to mechanically induced defects. Whereas slow q(+) led to the formation of the thermodynamically stable gamma polymorph, fast q(+) produced a significant amount of the metastable alpha polymorph. Mutual correlations between the macroscopic and microscopic crystal growth processes, and between the viscous flow and structural relaxation motions, were discussed based on the values of the corresponding activation energies. Notably, this approach helped us to distinguish between particular crystal growth modes in the case of the powdered indomethacin materials. Ediger's decoupling parameter was used to quantify the relationship between the viscosity and crystal growth. The link between the cooperativity of structural domains, parameters of the Tool-Narayanaswamy-Moynihan relaxation model and microscopic crystal growth was proposed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
<a href="/en/project/LM2018103" target="_blank" >LM2018103: Center of Materials and Nanotechnologies - Research Infrastructure</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Molecules
ISSN
1420-3049
e-ISSN
1420-3049
Volume of the periodical
27
Issue of the periodical within the volume
17
Country of publishing house
CH - SWITZERLAND
Number of pages
23
Pages from-to
"5668-1"-"5668-23"
UT code for WoS article
000851900500001
EID of the result in the Scopus database
2-s2.0-85137846656