Flow injection analysis of ranitidine based on derivatization reaction producing 2-methylfuran cation as a sensitive and selective amperometric detector
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F23%3A39919175" target="_blank" >RIV/00216275:25310/23:39919175 - isvavai.cz</a>
Result on the web
<a href="https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.202200318" target="_blank" >https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/10.1002/elan.202200318</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/elan.202200318" target="_blank" >10.1002/elan.202200318</a>
Alternative languages
Result language
angličtina
Original language name
Flow injection analysis of ranitidine based on derivatization reaction producing 2-methylfuran cation as a sensitive and selective amperometric detector
Original language description
A new electrochemical sensor in a flow injection system is developed for the determination of ranitidine in pharmaceutical formulations. The method is based on the deamination reaction of ranitidine in an acidic environment in the presence of nitrite ions producing the electroactive species 2-methylfuran and releasing nitrosamine [1]. A wide linear range of ranitidine from 4.4 to 6000 mg L−1, with correlation coefficient R2 = 0.996 and the detection limit 1.3 mg L−1 was obtained. The method has been applied in tablet analysis and ampoules; the results are within the confidence limits with 95% reliability compared to the reference method with HPLC.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Electroanalysis
ISSN
1040-0397
e-ISSN
1521-4109
Volume of the periodical
35
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
10
Pages from-to
"e202200318"
UT code for WoS article
000929356100001
EID of the result in the Scopus database
2-s2.0-85147556414