Centrifugally spun and ZnO-infiltrated PVA fibers with antibacterial activity for treatment of Acne vulgaris

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F25%3A39923106" target="_blank" >RIV/00216275:25310/25:39923106 - isvavai.cz</a>

Alternative codes found

RIV/62156489:43210/25:43926976

Result on the web

<a href="https://doi.org/10.1016/j.jconrel.2025.113777" target="_blank" >https://doi.org/10.1016/j.jconrel.2025.113777</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jconrel.2025.113777" target="_blank" >10.1016/j.jconrel.2025.113777</a>

Result language

angličtina

Original language name

Centrifugally spun and ZnO-infiltrated PVA fibers with antibacterial activity for treatment of Acne vulgaris

Original language description

The increasing spread of Acne vulgaris makes antibacterial agents increasingly important, especially for patients, who cannot use systemic antibacterial therapeutics. Recently, polymeric nano- and submicron-fibers with have attracted increasing interest in cosmetic and dermatological applications. Combined with the Vapor Phase Infiltration (VPI) process, the fibers serve as containers for the growth of metal oxides for a later use. We address the use of antibacterial agents by developing active antibacterial polymer-inorganic composites without any ZnO nanoparticles on the surface that are loose and would potentially detach. We fabricate poly(vinyl alcohol) fibers by centrifugal spinning and then infiltrate them with ZnO by applying 1 to 128 VPI cycles in the fluidized bed Atomic Layer Deposition reactor. The fibers&lt;acute accent&gt; morphology and structure is investigated by Scanning and Transmission Electron Microscopies and X-ray diffractometry. The presence of Zn and its uniform distribution on the surface is confirmed by scanning TEM Energy Dispersive X-ray spectroscopy. The prepared materials are subsequently tested for their antibacterial activity against Cutibacterium acnes and Staphylococcus epidermidis, main acne-causing bacteria. The results of antibacterial activity show that PVA fibers infiltrated with ZnO nanocrystals by &gt;32 VPI cycles effectively inhibit growth of the acne-causing bacteria. Moreover, the homogeneous distribution of ZnO nanocrystals infiltrated within the fibers ensures the immediate release of Zn2+ while preserving the fibrous structure, in contrast to fibers with nanoparticles prepared directly from the spinning solution. Therefore, the study suggests that the PVA fibers infiltrated with ZnO exhibit promising potential as a material for anti-acne face masks.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10400 - Chemical sciences

Project

<a href="/en/project/EF16_025%2F0007314" target="_blank" >EF16_025/0007314: Multidisciplinary research to increase application potential of nanomaterials in agricultural practice</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Controlled Release

ISSN

0168-3659

e-ISSN

1873-4995

Volume of the periodical

383

Issue of the periodical within the volume

July 2025

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

10

Pages from-to

113777

UT code for WoS article

001494716700001

EID of the result in the Scopus database

2-s2.0-105003702100