Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26110%2F24%3APU152286" target="_blank" >RIV/00216305:26110/24:PU152286 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/24:00080714 RIV/00216224:14110/24:00137257

Result on the web

<a href="https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1417996" target="_blank" >https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2024.1417996</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2024.1417996" target="_blank" >10.3389/fnins.2024.1417996</a>

Result language

angličtina

Original language name

Subjective visual sensitivity in neurotypical adults: insights from a magnetic resonance spectroscopy study

Original language description

Introduction Altered subjective visual sensitivity manifests as feelings of discomfort or overload elicited by intense and irritative visual stimuli. This can result in a host of visual aberrations including visual distortions, elementary visual hallucinations and visceral responses like dizziness and nausea, collectively referred to as "pattern glare." Current knowledge of the underlying neural mechanisms has focused on overall excitability of the visual cortex, but the individual contribution of excitatory and inhibitory systems has not yet been quantified.Methods In this study, we focus on the role of glutamate and gamma-aminobutyric acid (GABA) as potential mediators of individual differences in subjective visual sensitivity, measured by a computerized Pattern Glare Test-a series of monochromatic square-wave gratings with three different spatial frequencies, while controlling for psychological variables related to sensory sensitivity with multiple questionnaires. Resting neurotransmitter concentrations in primary visual cortex (V1) and right anterior insula were studied in 160 healthy participants using magnetic resonance spectroscopy.Results Data showed significant differences in the perception of visual distortions (VD) and comfort scores between men and women, with women generally reporting more VD, and therefore the modulatory effect of sex was considered in a further examination. A general linear model analysis showed a negative effect of occipital glutamate on a number of reported visual distortions, but also a significant role of several background psychological traits. When assessing comfort scores in women, an important intervening variable was the menstrual cycle.Discussion Our findings do not support that baseline neurotransmitter levels have a significant role in overreactivity to aversive stimuli in neurotypical population. However, we demonstrated that biological sex can have a significant impact on subjective responses. Based on this additional fi

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30100 - Basic medicine

Project

<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2024

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neuroscience

ISSN

1662-453X

e-ISSN

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Volume of the periodical

18

Issue of the periodical within the volume

1

Country of publishing house

CH - SWITZERLAND

Number of pages

16

Pages from-to

„“-„“

UT code for WoS article

001329604100001

EID of the result in the Scopus database

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